abstract：:Aging causes various functional changes, including cognitive impairment and inflammatory responses in the brain. Transient receptor potential melastatin 2 (TRPM2), a Ca2+-permeable channel expressed abundantly in immune cells, exacerbates inflammatory responses. Previously, we reported that TRPM2 on resident microglia...

journal_title：Neuroscience

authors： Kakae M,Miyanohara J,Morishima M,Nagayasu K,Mori Y,Shirakawa H,Kaneko S

更新日期：2019-06-01 00:00:00

abstract：:Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...

journal_title：Neuroscience

authors： Tsoy A,Saliev T,Abzhanova E,Turgambayeva A,Kaiyrlykyzy A,Akishev M,Saparbayev S,Umbayev B,Askarova S

更新日期：2019-06-01 00:00:00

abstract：:Overexpression of vascular endothelial growth factor (VEGF) is considered the most critical factor in radiation-induced brain injury (RBI). To investigate the role of VEGF and the mechanism underlying microvascular damage in RBI, wild type mice, and transgenic mice overexpressing VEGF derived from astrocytes, were sep...

journal_title：Neuroscience

authors： Zhou D,Huang X,Xie Y,Deng Z,Guo J,Huang H

更新日期：2019-06-01 00:00:00

abstract：:It is commonly recognized that physical exercise positively affects several CNS regions and improves cognitive abilities. For example, exercise is associated with an increase in neurogenesis and facilitation of long-term potentiation in the hippocampus. Conversely, animal models for depression are associated with a de...

journal_title：Neuroscience

authors： Dahlin E,Andersson M,Thorén A,Hanse E,Seth H

更新日期：2019-06-01 00:00:00

abstract：:Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contr...

journal_title：Neuroscience

authors： Bharadwaj HM,Mai AR,Simpson JM,Choi I,Heinz MG,Shinn-Cunningham BG

更新日期：2019-05-21 00:00:00

abstract：:Neuroinflammation is associated with increased vulnerability to diverse psychiatric conditions, including treatment-resistant major depressive disorder (MDD). Here we assessed whether high fat diet (HFD) induced neuroinflammation may be suitable to model a treatment-resistant depressive-like brain state in mice. Male ...

journal_title：Neuroscience

authors： Feng M,Crowley NA,Patel A,Guo Y,Bugni SE,Luscher B

更新日期：2019-05-15 00:00:00

abstract：:Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning ...

journal_title：Neuroscience

authors： Manning CE,Eagle AL,Kwiatkowski CC,Achargui R,Woodworth H,Potter E,Ohnishi Y,Leinninger GM,Robison AJ

更新日期：2019-05-15 00:00:00

abstract：:Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

journal_title：Neuroscience

authors： Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

更新日期：2019-05-15 00:00:00

abstract：:The adverse consequences of early-life sleep deprivation on mental health are well recognized, yet many aspects remain unknown, therefore, animal studies can offer useful insights. Male Sprague-Dawley rats at postnatal day (PND) 19 were subjected to sleep deprivation (SD) for 14 days (6-8 hours/day). Control (CON) rat...

journal_title：Neuroscience

authors： Atrooz F,Liu H,Kochi C,Salim S

更新日期：2019-05-15 00:00:00

abstract：:Conductive hearing loss is a prevalent condition globally. It remains unclear whether conductive hearing loss that occurs during early development disrupts auditory peripheral systems. In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal ...

journal_title：Neuroscience

authors： Qi Y,Yu S,Du Z,Qu T,He L,Xiong W,Wei W,Liu K,Gong S

更新日期：2019-05-15 00:00:00

abstract：:Methamphetamine (MA), neurotoxic drug of abuse, causes cell death in vitro and in vivo via several mechanisms such as mitochondrial dysfunction. In this study we evaluated the effect of MA on cell viability and mitochondrial biogenesis in primary midbrain culture. Primary mesencephalon cells prepared from E14.5 rat em...

journal_title：Neuroscience

authors： Valian N,Heravi M,Ahmadiani A,Dargahi L

更新日期：2019-05-15 00:00:00

abstract：:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated ...

journal_title：Neuroscience

authors： Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren K

更新日期：2019-05-01 00:00:00

abstract：:Effective information transmission for open skill performance requires fine-scale coordination of distributed networks of brain regions linked by white matter tracts. However, how patterns of connectivity in these anatomical pathways may improve global efficiency remains unclear. In this study, we hypothesized that th...

journal_title：Neuroscience

authors： Zhu H,Pi YL,Qiu FH,Wang FJ,Liu K,Ni Z,Wu Y,Zhang J

更新日期：2019-04-15 00:00:00

abstract：:The pedunculopontine nucleus (PPN) shows altered electrophysiological and anatomic characteristics in Parkinson's disease (PD), but little is known about the effect of 6-hydroxydopamine (6-OHDA) lesion and levodopa (L-DOPA) therapy on the relationship between spike and local field potential (LFP) activities in the PPN...

journal_title：Neuroscience

authors： Geng X,Wang X,He F,Zhang X,Xie J,Gao G,Han H,Yao X,Zhang H,Gao Y,Wang Y,Wang M

更新日期：2019-04-15 00:00:00

abstract：:We have previously shown how the Frontal Pole cortex (FPC) neurons play a unique role in both the monitoring and evaluating of self-generated decisions during feedback in a visually cued strategy task. For each trial of this task, a cue instructed one of two strategies: to either stay with the previous goal or shift t...

journal_title：Neuroscience

authors： Mione V,Tsujimoto S,Genovesio A

更新日期：2019-04-15 00:00:00

abstract：:FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR. Its association with mental disorders has been identified, but its function in disease development is largely unknown. Long-term potentiation (LTP) is a functiona...

journal_title：Neuroscience

authors： Qiu B,Xu Y,Wang J,Liu M,Dou L,Deng R,Wang C,Williams KE,Stewart RB,Xie Z,Ren W,Zhao Z,Shou W,Liang T,Yong W

更新日期：2019-03-15 00:00:00

abstract：:Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤P10) development. It is unclear how chorda tympani soma and terminal fields are affecte...

journal_title：Neuroscience

authors： Martin LJ,Lane AH,Samson KK,Sollars SI

更新日期：2019-03-15 00:00:00

abstract：:Intrauterine growth restriction (IUGR) associates with increased preference for palatable foods and altered insulin sensitivity. Insulin modulates the central dopaminergic response and changes behavioral responses to reward. We measured the release of dopamine in the accumbens during palatable food intake in IUGR rats...

journal_title：Neuroscience

authors： Laureano DP,Alves MB,Miguel PM,Machado TD,Reis AR,Mucellini AB,Cunha FS,Lampert C,Salvador APA,Dalle Molle R,Mosca PR,Pokhvisneva I,Desai M,Ross MG,Silveira PP

更新日期：2019-02-21 00:00:00

abstract：:Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission by targeting the most redox-sensitive presynaptic compartment (Ginia...

journal_title：Neuroscience

authors： Giniatullin A,Petrov A,Giniatullin R

更新日期：2019-02-10 00:00:00

abstract：:Peripheral diabetic neuropathy (PDN) manifests in 50-60% of type I and II diabetic patients and is the major cause of limb amputation. Adequate therapy for PDN is a current challenge. There are evidences that the activation of the P2X4 receptor (P2X4R) expressed on microglial cells of the central nervous system takes ...

journal_title：Neuroscience

authors： Teixeira JM,Dos Santos GG,Neves AF,Athie MCP,Bonet IJM,Nishijima CM,Farias FH,Figueiredo JG,Hernandez-Olmos V,Alshaibani S,Tambeli CH,Müller CE,Parada CA

更新日期：2019-02-01 00:00:00

abstract：:γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the b...

journal_title：Neuroscience

authors： Zhuang L,Zhang B,Qin Z,Wang P

更新日期：2019-02-01 00:00:00

abstract：:Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been sh...

journal_title：Neuroscience

authors： Dutar P,Tolle V,Kervern M,Carcenac C,Carola V,Gross C,Savasta M,Darmon M,Masson J

更新日期：2019-01-01 00:00:00

abstract：:Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD. The majority of individuals with ASD exhibit adverse reactions to sensory stimuli and auditory dysfunction. Previous studies of animals expo...

journal_title：Neuroscience

authors： Mansour Y,Mangold S,Chosky D,Kulesza RJ Jr

更新日期：2019-01-01 00:00:00

abstract：:Seipin is a widely expressed protein but with highest levels found in the brain and testes. Seipin function is not yet completely understood, therefore the aim of this study was to evaluate the expression of BSCL2 transcripts in the central nervous system (CNS) of humans and investigate the effect of their overexpress...

journal_title：Neuroscience

authors： Sánchez-Iglesias S,Fernández-Liste A,Guillín-Amarelle C,Rábano A,Rodriguez-Cañete L,González-Méndez B,Fernández-Pombo A,Senra A,Araújo-Vilar D

更新日期：2019-01-01 00:00:00

abstract：:Ghrelin is a peptide produced in the gut with a wide range of physiological functions. Recent studies have suggested it may have potential as a neuroprotective agent in models of Parkinson's disease, reducing the impact of toxic challenges on the survival of nigral dopaminergic neurons. The presence of the ghrelin rec...

journal_title：Neuroscience

authors： Elabi OF,Duskova K,Davies JS,Lane EL

更新日期：2018-12-15 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with no effective method for its treatment so far. The pathogenesis of AD has been reported, but the endogenous metabolic profile and disease-related biomarkers are still not clear. To better understand AD, an AD model induced by injecting β-amyloid...

journal_title：Neuroscience

authors： Liu Y,Wei M,Yue K,Hu M,Li S,Men L,Pi Z,Liu Z,Liu Z

更新日期：2018-12-01 00:00:00

abstract：:Stimulation of the mu-opioid receptor (MOR) on nociceptors with fentanyl can produce hyperalgesia (opioid-induced hyperalgesia, OIH) and hyperalgesic priming, a model of transition to chronic pain. We investigated if local and systemic administration of biased MOR agonists (PZM21 and TRV130 [oliceridine]), which prefe...

journal_title：Neuroscience

authors： Araldi D,Ferrari LF,Levine JD

更新日期：2018-12-01 00:00:00

abstract：:Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might increase the understanding of sites of action, and mechanisms related to headache therapy. The overall aim of the study was to investigate the presence of migraine targets in the TG with particular emphasis on pituitary adenylate cy...

journal_title：Neuroscience

authors： Frederiksen SD,Warfvinge K,Ohlsson L,Edvinsson L

更新日期：2018-11-21 00:00:00

abstract：:The present study set out to assess the possible role of the medial prefrontal cortex (mPFC) cannabinoid CB1 receptors and BDNF/cFOS signaling pathways in morphine-dextromethorphan (DXM) cross state-dependent memory (SDM) using male Wistar rats. Changes on the levels of BDNF and cFOS proteins in the PFC were examined ...

journal_title：Neuroscience

authors： Ghasemzadeh Z,Rezayof A

更新日期：2018-11-21 00:00:00

abstract：:Using data from time-resolved cortical stimulation, intracranial neural recordings, and focal surgical resections, Lee et al. (2018) demonstrate that a small area within left posterior superior temporal gyrus (pSTG) supports the ability to produce functional morphemes but not other basic aspects of language production...

journal_title：Neuroscience

authors： Fedorenko E,Williams ZM,Ferreira VS

更新日期：2018-11-10 00:00:00

abstract：:The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with...

journal_title：Neuroscience

authors： David J,O'Toole E,O'Reilly K,Thuery G,Assmann N,Finlay D,Harkin A

更新日期：2018-11-10 00:00:00

abstract：:Ghrelin is a stomach-derived hormone that regulates rewarding behaviors and reinforcement by acting on the ventral tegmental area (VTA). The VTA is a complex midbrain structure mainly comprised of dopamine (DA) and gamma-aminobutiric acid (GABA) neurons that are distributed in several VTA sub-nuclei. Here, we investig...

journal_title：Neuroscience

authors： Cornejo MP,Barrile F,De Francesco PN,Portiansky EL,Reynaldo M,Perello M

更新日期：2018-11-10 00:00:00

abstract：:2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside (salidroside analog-4g, SalA-4g), has shown neuroprotective prospects for the treatment of ischemic stroke. However, the dose-response and time window study for SalA-4g, and the mechanism of SalA-4g-mediated neuroprotection remain unclear. Here, we systematic...

journal_title：Neuroscience

authors： Yu S,Xu H,Chi X,Wei L,Cheng Q,Yang Y,Zhou C,Ding F

更新日期：2018-11-01 00:00:00

abstract：:In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presy...

journal_title：Neuroscience

authors： Wang H,Shen S,Zheng T,Bi L,Li B,Wang X,Yang Y,Jen PH

更新日期：2018-10-15 00:00:00

abstract：:Stress plays a pivotal role in the development and/or exacerbation of functional gastrointestinal (GI) disorders. The paraventricular nucleus of the hypothalamus (PVN) contains neurons that are part of the hypothalamic-pituitary-adrenal axis as well as preautonomic neurons innervating, among other areas, gastric-proje...

journal_title：Neuroscience

authors： Jiang Y,Coleman FH,Kopenhaver Doheny K,Travagli RA

更新日期：2018-10-15 00:00:00

abstract：:The promotion of angiogenesis is a promising therapeutic strategy for ischemic stroke. Many long noncoding RNAs (lncRNAs) are related to angiogenesis following ischemic stroke. LncRNA small nucleolar RNA host gene 12 (SNHG12) was upregulated in oxygen-glucose deprivation (OGD)-exposed primary brain microvascular endot...

journal_title：Neuroscience

authors： Zhao M,Wang J,Xi X,Tan N,Zhang L

更新日期：2018-10-15 00:00:00

abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

journal_title：Neuroscience

authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

更新日期：2018-10-15 00:00:00

abstract：:Pairing vagus nerve stimulation (VNS) with movements or sounds can direct robust plasticity in motor or auditory cortex, respectively. The degree of map plasticity is influenced by the intensity and pulse width of VNS, number of VNS-event pairings, and the interval between each pairing. It is likely that these paramet...

journal_title：Neuroscience

authors： Loerwald KW,Buell EP,Borland MS,Rennaker RL 2nd,Hays SA,Kilgard MP

更新日期：2018-09-15 00:00:00

abstract：:Neuronal apoptosis plays important roles in the early brain injury after subarachnoid hemorrhage (SAH). This study first showed that inhibition of activating transcription factor 6 (ATF6) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-mediated apoptosis and blood-brain-barrier (BBB) disruption after SAH. ...

journal_title：Neuroscience

authors： Xu W,Gao L,Li T,Zheng J,Shao A,Zhang J

更新日期：2018-09-15 00:00:00

abstract：:Preclinical and clinical studies support a promising, albeit not definitive, neuroprotective effect of emergent uric acid (UA) administration in ischemic stroke. We assessed the effects of UA in an ischemic stroke model relevant to the current treatment paradigm of mechanical thrombectomy within the STAIR/RIGOR recomm...

journal_title：Neuroscience

authors： Aliena-Valero A,López-Morales MA,Burguete MC,Castelló-Ruiz M,Jover-Mengual T,Hervás D,Torregrosa G,Leira EC,Chamorro Á,Salom JB

更新日期：2018-09-15 00:00:00